Across TCGA cell cohorts, HEPN1 mutation is significantly associated with the mutation status of many other genes, with 1,867 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HEPN1-associated genes across cancer lineages are NELFB, TNC, and PIK3CB. Each is linked with HEPN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HEPN1-to-partner and partner-to-HEPN1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEPN1→partner) and Y-score (partner→HEPN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	NELFB →	+5.502	+5.502	.003	.003	1	2
SOFT_TISSUE	TNC →	+4.502	+5.066	.007	.007	1	2
SOFT_TISSUE	PIK3CB →	+5.502	+5.502	.003	.003	1	2
LARGE_INTESTINE	NHS →	+2.422	+4.050	.004	.004	1	2
LARGE_INTESTINE	PLXNB3 →	+2.422	+4.050	.004	.004	1	2
LARGE_INTESTINE	SLC9A7 →	+3.744	+5.000	<.001	<.001	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,867 associations by consensus.

Exploration

HEPN1 survival (RNA) · tumor vs normal (RNA) · all HEPN1 data types