HEPH

Across TCGA pan-cancer cohorts, HEPH Mutation is linked to patient survival in 13 of 34 cancer types, making it a survival-associated HEPH data layer compared with 20 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher HEPH Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated HEPH expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

COAD, MESO, and UCEC are the cancer types where HEPH Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.415	0.762	<.001	48	view →
MESO	OS	Median	III,IV	0.077	0.580	<.001	42	view →
UCEC	DFS	Median	All	0.957	0.822	.004	34	view →
DLBC	OS	Median	II,III,IV	0.172	0.949	<.001	30	view →
STAD	OS	Median	II,III,IV	0.271	0.714	.004	18	view →
ESCA	OS	Median	All	0.198	0.872	.003	18	view →
LUSC	OS	Median	III,IV	0.136	0.610	.014	7	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
LIHC	DFS	Median	II,III,IV	0.044	0.427	<.001	6	view →
LUAD	DFS	Median	III,IV	1.000	0.619	.020	6	view →
SCLC	OS	Median	II,III,IV	0.811	0.381	.041	4	view →
BLCA	OS	Median	II,III,IV	0.897	0.421	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

HEPH–COAD (DFS)

Open the COAD breakdown →