HEPH

Across TCGA pan-cancer cohorts, HEPH RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of HEPH’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where HEPH RNA is repressed in tumor relative to normal tissue. In most cancer types HEPH is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

KICH, HNSC, and KIRP are the cancer types where HEPH tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HEPH RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	III,IV	−2.128	<.001	11	view →
HNSC	All	All	+0.769	<.001	11	view →
KIRP	Female	All	−1.556	<.001	9	view →
BLCA	Male	III,IV	−2.237	<.001	8	view →
UCEC	All	All	−1.753	<.001	6	view →
COAD	Female	II,III,IV	−0.955	<.001	4	view →
LUSC	All	All	−0.603	<.001	4	view →
BRCA	Female	All	−0.351	.002	4	view →
CHOL	All	All	+1.237	.001	3	view →
LIHC	Female	All	+0.552	.005	3	view →
PRAD	All	All	−1.016	<.001	2	view →
THCA	All	II,III,IV	−0.617	.017	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

HEPH–KICH

Open the KICH breakdown →