HEPH

Across TCGA pan-cancer cohorts, HEPH mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated HEPH data layer compared with 20 for mass-spec protein and 13 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher HEPH mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated HEPH expression acts as an unfavorable survival marker, although some lineages such as COAD and CCRCC show a favorable association.

COAD, CCRCC, and PDAC are the cancer types where HEPH mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	II,III,IV	1.000	0.897	.019	42	view →
CCRCC	DFS	Tertile	III,IV	0.891	0.297	.014	17	view →
PDAC	DFS	Quartile	III,IV	0.214	0.891	.002	9	view →
LSCC	OS	Median	All	0.748	1.000	.006	6	view →
UCEC	DFS	Median	All	0.936	1.000	.035	4	view →
HNSC	DFS	Quartile	IV	0.524	0.946	.041	2	view →
GBM	OS	Quartile	All	0.720	0.901	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

HEPH–COAD (DFS)

Open the COAD breakdown →