HEPH

Across TCGA patient cohorts, HEPH mutation is significantly associated with the total protein of many other genes, with 66 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HEPH-associated genes across cancer lineages are Rad50, Cyclin-B1, and Stathmin. Each is linked with HEPH in more than 3 cancer types. Because this analysis shows association rather than direction, both HEPH-to-partner and partner-to-HEPH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by HEPH-low versus HEPH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEPH→partner) and Y-score (partner→HEPH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.151	-1.000	.021	.026	3	4
LUAD	Cyclin-B1 →	+0.526	+3.000	.006	<.001	3	3
SKCM	Stathmin →	+0.126	+1.157	.011	.012	3	3
LUAD	FOXO3a_pS318_S321 →	-0.117	-3.459	.004	.005	3	2
LUAD	p62 Lck ligand →	+0.570	+1.824	.001	.015	3	2
LUAD	YAP_pS127 →	-0.370	-1.807	.009	.026	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

Rad50 by HEPH expression — UCEC

Explore this box plot interactively →