HEPH

Across TCGA cell cohorts, HEPH RNA expression is significantly associated with the go_rna of many other GO terms, with 4,486 significant associations in total. BONE shows the largest number of these associations.

The most reproducible HEPH-associated GO terms across cancer lineages are Regulation of iron ion transmembrane transport, Regulation of amyloid-beta clearance, and Positive regulation of iron ion transport. Each is linked with HEPH in more than 7 cancer types. Because this analysis shows association rather than direction, both HEPH-to-partner and partner-to-HEPH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of iron ion transmembrane transport grouped by HEPH-low versus HEPH-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HEPH→partner) and Y-score (partner→HEPH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of iron ion transmembrane transport →	-0.426	-2.206	<.001	<.001	3	8
BONE	Regulation of amyloid-beta clearance →	+0.154	+2.281	.002	.001	3	7
CNS	Positive regulation of iron ion transport →	+0.861	+2.593	.004	<.001	3	7
CNS	Positive regulation of iron ion transmembrane transport →	+0.861	+2.593	.004	<.001	3	7
LARGE_INTESTINE	Protein folding in endoplasmic reticulum →	+0.053	+2.275	.001	<.001	3	7
BONE	Viral process →	+0.105	+2.415	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,486 associations by consensus.

Regulation of iron ion transmembrane transport by HEPH expression — BONE

Explore this box plot interactively →