HEPH

Across TCGA cell cohorts, HEPH mutation is significantly associated with the RNA expression of many other genes, with 508 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HEPH-associated genes across cancer lineages are GALR3, OR1L3, and ADAM7. Each is linked with HEPH in more than 1 cancer types. Because this analysis shows association rather than direction, both HEPH-to-partner and partner-to-HEPH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GALR3 grouped by HEPH-low versus HEPH-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEPH→partner) and Y-score (partner→HEPH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GALR3 →	+0.123	+3.519	<.001	.007	3	2
BLOOD_Leukemia	OR1L3 →	+0.075	+4.276	<.001	.007	3	2
LARGE_INTESTINE	ADAM7 →	+0.003	+2.538	<.001	.005	3	2
SOFT_TISSUE	SPRR1B →	+0.138	+3.142	<.001	.008	3	1
SOFT_TISSUE	ABHD16B →	+0.372	+3.906	<.001	.002	3	1
SOFT_TISSUE	BHLHA9 →	+0.018	+3.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 508 associations by consensus.

GALR3 by HEPH expression — SOFT_TISSUE

Explore this box plot interactively →