HENMT1

Across TCGA patient cohorts, HENMT1 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HENMT1-associated genes across cancer lineages are ATM, 14-3-3_beta, and FoxM1. Each is linked with HENMT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HENMT1-to-partner and partner-to-HENMT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by HENMT1-low versus HENMT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HENMT1→partner) and Y-score (partner→HENMT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.556	-2.446	.002	.018	3	2
UCEC	14-3-3_beta →	-0.094	-2.973	.020	.035	3	1
UCEC	FoxM1 →	+0.221	+2.179	.034	.034	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.419	+1.906	.040	.016	3	1
UCEC	JNK_pT183_Y185 →	-0.202	-2.584	.002	.010	3	1
UCEC	JNK2 →	+0.233	+1.906	.003	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

ATM by HENMT1 expression — UCEC

Explore this box plot interactively →