HEMGN

Across TCGA patient cohorts, HEMGN mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HEMGN-associated genes across cancer lineages are eIF4E, ASNS, and ATM. Each is linked with HEMGN in more than 1 cancer types. Because this analysis shows association rather than direction, both HEMGN-to-partner and partner-to-HEMGN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by HEMGN-low versus HEMGN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEMGN→partner) and Y-score (partner→HEMGN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.151	+3.335	.025	.005	3	2
UCEC	ASNS →	+0.466	+1.999	<.001	.002	3	2
UCEC	ATM →	-0.397	-1.289	.006	.023	3	2
UCEC	Caspase-7-cleavedD198 →	+0.425	+1.434	.025	.027	3	2
UCEC	C-Raf →	+0.155	+1.523	<.001	.008	3	2
UCEC	14-3-3_beta →	-0.089	-1.880	.005	.014	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

eIF4E by HEMGN expression — UCEC

Explore this box plot interactively →