HEMGN

Across TCGA pan-cancer cohorts, HEMGN RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of HEMGN’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where HEMGN RNA is repressed in tumor relative to normal tissue. In most cancer types HEMGN is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

THCA, LUAD, and COAD are the cancer types where HEMGN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HEMGN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.530	<.001	11	view →
LUAD	All	III,IV	−0.448	<.001	9	view →
COAD	All	II,III,IV	−0.129	<.001	9	view →
LUSC	All	III,IV	−0.595	<.001	8	view →
BLCA	All	IV	−0.068	.022	2	view →
BRCA	All	III,IV	−0.060	.010	2	view →
READ	All	All	−0.203	.042	1	view →
KIRC	Male	All	+0.195	.017	1	view →
LIHC	Male	All	−0.055	.006	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

HEMGN–THCA

Open the THCA breakdown →