HELZ2

Across TCGA patient cohorts, HELZ2 protein abundance is significantly associated with the RNA expression of many other genes, with 14,939 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible HELZ2-associated genes across cancer lineages are OAS3, OAS2, and MX1. Each is linked with HELZ2 in more than 9 cancer types. Because this analysis shows association rather than direction, both HELZ2-to-partner and partner-to-HELZ2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HELZ2 versus OAS3 in OV, with a Pearson correlation of 0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HELZ2→partner) and Y-score (partner→HELZ2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	OAS3 →	+1.461	+0.405	<.001	.004	3	10
LSCC	OAS2 →	+1.459	+0.530	<.001	<.001	3	9
BRCA	MX1 →	+1.684	+0.488	<.001	<.001	3	9
HNSC	NRIR →	+1.006	+0.468	<.001	<.001	3	9
OV	PARP12 →	+1.102	+0.726	<.001	<.001	3	9
UCEC	OAS1 →	+1.273	+0.455	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,939 associations by consensus.

HELZ2 vs OAS3 — OV

Explore this scatter interactively →