HELZ2

Across TCGA patient cohorts, HELZ2 mutation is significantly associated with the RNA expression of many other genes, with 3,739 significant associations in total. COAD shows the largest number of these associations.

The most reproducible HELZ2-associated genes across cancer lineages are CHAF1A, GAS2L1, and BCL11A. Each is linked with HELZ2 in more than 5 cancer types. Because this analysis shows association rather than direction, both HELZ2-to-partner and partner-to-HELZ2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHAF1A grouped by HELZ2-low versus HELZ2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HELZ2→partner) and Y-score (partner→HELZ2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CHAF1A →	+0.378	+2.700	.004	.005	3	6
COAD	GAS2L1 →	+0.530	+1.925	.001	.005	3	5
COAD	BCL11A →	-0.519	-1.925	.004	.005	3	5
SKCM	SENP3-EIF4A1 →	+0.162	+2.065	<.001	.001	3	5
COAD	ULBP2 →	+1.258	+2.920	<.001	<.001	3	4
SKCM	MON1A →	+0.323	+1.662	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,739 associations by consensus.

CHAF1A by HELZ2 expression — COAD

Explore this box plot interactively →