Across TCGA cell cohorts, HELT mutation is significantly associated with the mutation status of many other genes, with 1,571 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HELT-associated genes across cancer lineages are PHF14, SGIP1, and SLC24A1. Each is linked with HELT in more than 2 cancer types. Because this analysis shows association rather than direction, both HELT-to-partner and partner-to-HELT results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HELT→partner) and Y-score (partner→HELT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PHF14 →	+4.321	+5.285	.005	.005	1	3
BLOOD_Leukemia	SGIP1 →	+4.321	+5.285	.005	.005	1	3
LARGE_INTESTINE	SLC24A1 →	+2.407	+2.886	.008	.008	1	3
LARGE_INTESTINE	HIVEP3 →	+1.630	+3.584	.004	.004	1	3
LARGE_INTESTINE	CEP170 →	+1.836	+2.906	.009	.009	1	3
BLOOD_Leukemia	PAQR9 →	+4.736	+5.560	.003	.003	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,571 associations by consensus.

Exploration

HELT survival (RNA) · tumor vs normal (RNA) · all HELT data types