HELQ

Across TCGA cell cohorts, HELQ RNA expression is significantly associated with the RNA expression of many other genes, with 10,606 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HELQ-associated genes across cancer lineages are LIN54, COPS4, and G3BP2. Each is linked with HELQ in more than 17 cancer types. Because this analysis shows association rather than direction, both HELQ-to-partner and partner-to-HELQ results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HELQ versus LIN54 in UPPER_AERODIGESTIVE_TRACT, with a Pearson correlation of 0.68.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HELQ→partner) and Y-score (partner→HELQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	LIN54 →	+0.979	+1.043	<.001	<.001	3	18
LARGE_INTESTINE	COPS4 →	+0.976	+0.786	<.001	<.001	3	18
PANCREAS	G3BP2 →	+1.220	+0.660	<.001	<.001	3	17
BLOOD_Lymphoma	SMARCAD1 →	+1.037	+0.835	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	PRMT9 →	+0.815	+0.980	<.001	<.001	3	16
BLOOD_Lymphoma	HNRNPD →	+1.153	+0.872	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,606 associations by consensus.

HELQ vs LIN54 — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →