HELLS

Across TCGA patient cohorts, HELLS protein abundance is significantly associated with the protein abundance of many other proteins, with 26,926 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HELLS-associated proteins across cancer lineages are MKI67, NCAPG, and NCAPG_S674. Each is linked with HELLS in more than 8 cancer types. Because this analysis shows association rather than direction, both HELLS-to-partner and partner-to-HELLS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HELLS versus MKI67 in GBM, with a Pearson correlation of 0.70.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HELLS→partner) and Y-score (partner→HELLS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MKI67 →	+0.967	+0.939	<.001	<.001	3	9
GBM	NCAPG →	+0.821	+0.950	<.001	<.001	3	9
LUAD	NCAPG_S674 →	+1.248	+0.544	<.001	<.001	3	9
PDAC	CAPNS1 →	-0.497	-0.934	<.001	<.001	3	8
LUAD	CDK1 →	+0.918	+0.566	<.001	<.001	3	8
LUAD	API5_S464 →	+0.906	+0.465	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 26,926 associations by consensus.

HELLS vs MKI67 — GBM

Explore this scatter interactively →