HELLS

Across TCGA patient cohorts, HELLS mutation is significantly associated with the RNA expression of many other genes, with 2,118 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HELLS-associated genes across cancer lineages are RNU6-522P, HSPE1P1, and RN7SKP221. Each is linked with HELLS in more than 1 cancer types. Because this analysis shows association rather than direction, both HELLS-to-partner and partner-to-HELLS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-522P grouped by HELLS-low versus HELLS-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HELLS→partner) and Y-score (partner→HELLS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-522P →	+0.249	+4.555	<.001	<.001	3	2
LUAD	HSPE1P1 →	+0.133	+5.748	<.001	.001	3	2
BRCA	RN7SKP221 →	+0.099	+8.471	<.001	.005	3	2
BLCA	POU5F1P2 →	+0.032	+4.314	.001	.009	3	2
SKCM	MIR4642 →	+0.502	+3.032	.002	.009	3	2
LUSC	RNU6-370P →	+0.311	+4.548	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,118 associations by consensus.

RNU6-522P by HELLS expression — SKCM

Explore this box plot interactively →