HELLPAR

Across TCGA patient cohorts, HELLPAR mutation is significantly associated with the RNA expression of many other genes, with 829 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HELLPAR-associated genes across cancer lineages are HMGXB4, MCAT, and FAM118A. Each is linked with HELLPAR in more than 1 cancer types. Because this analysis shows association rather than direction, both HELLPAR-to-partner and partner-to-HELLPAR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGXB4 grouped by HELLPAR-low versus HELLPAR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HELLPAR→partner) and Y-score (partner→HELLPAR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HMGXB4 →	+0.576	+3.470	.009	.003	3	1
UCEC	MCAT →	+0.542	+3.212	.002	.009	3	1
UCEC	FAM118A →	+0.614	+3.470	.002	.003	3	1
UCEC	TRMU →	+0.576	+3.201	<.001	.009	3	1
UCEC	CNIH1 →	+0.674	+3.202	.001	.009	3	1
UCEC	VRK1 →	+0.751	+3.480	.005	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 829 associations by consensus.

HMGXB4 by HELLPAR expression — UCEC

Explore this box plot interactively →