HELLPAR

Across TCGA patient cohorts, HELLPAR mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HELLPAR-associated genes across cancer lineages are A-Raf_pS299, JNK2, and p27_pT157. Each is linked with HELLPAR in more than 1 cancer types. Because this analysis shows association rather than direction, both HELLPAR-to-partner and partner-to-HELLPAR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by HELLPAR-low versus HELLPAR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HELLPAR→partner) and Y-score (partner→HELLPAR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.188	-3.169	.001	.019	3	1
UCEC	JNK2 →	+0.348	+3.026	<.001	.018	3	1
UCEC	p27_pT157 →	-0.067	-2.960	.022	.036	3	1
UCEC	Tuberin →	+0.540	+3.179	<.001	.010	3	1
UCEC	Caspase-8 →	-0.362	-3.143	.004	.018	3	1
UCEC	C-Raf →	+0.223	+2.321	.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

A-Raf_pS299 by HELLPAR expression — UCEC

Explore this box plot interactively →