HEIH

Across TCGA patient cohorts, HEIH RNA expression is significantly associated with the go_rna of many other GO terms, with 7,153 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible HEIH-associated GO terms across cancer lineages are Bile acid signaling pathway, Response to actinomycin D, and Peroxisome fission. Each is linked with HEIH in more than 15 cancer types. Because this analysis shows association rather than direction, both HEIH-to-partner and partner-to-HEIH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bile acid signaling pathway grouped by HEIH-low versus HEIH-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HEIH→partner) and Y-score (partner→HEIH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Bile acid signaling pathway →	-0.089	-0.449	.004	.001	3	15
SARC	Response to actinomycin D →	+0.040	+0.425	<.001	.002	2	15
THCA	Peroxisome fission →	+0.057	+0.639	<.001	<.001	3	14
DLBC	Lysosomal lumen acidification →	+0.033	+0.725	.002	<.001	1	16
TGCT	Sequestering of iron ion →	+0.064	+0.469	<.001	<.001	3	14
PCPG	Obsolete histone H3-K4 methylation →	+0.048	+0.589	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,153 associations by consensus.

Bile acid signaling pathway by HEIH expression — ESCA

Explore this box plot interactively →