HEIH

Across TCGA pan-cancer cohorts, HEIH RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated HEIH data layer.

The strongest signal is observed in mesothelioma (MESO), where higher HEIH RNA is associated with better overall survival. In most high-consensus cancer types, elevated HEIH expression acts as an unfavorable survival marker, although some lineages such as MESO and KIRC show a favorable association.

MESO, KIRC, and PAAD are the cancer types where HEIH RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.501	0.273	<.001	108	view →
KIRC	DFS	Median	All	0.734	0.517	<.001	102	view →
PAAD	DFS	Median	All	0.418	0.144	<.001	40	view →
SARC	OS	Median	All	0.892	0.781	.001	34	view →
LAML	DFS	Quartile	All	0.177	0.518	<.001	30	view →
LUSC	OS	Quartile	II,III,IV	0.291	0.617	.001	27	view →
GBM	OS	Quartile	All	0.337	0.537	.007	18	view →
DLBC	DFS	Tertile	All	1.000	0.542	.024	16	view →
BLCA	DFS	Quartile	III,IV	0.619	0.352	.008	16	view →
ESCA	OS	Tertile	IV	0.219	0.864	.024	12	view →
CHOL	OS	Tertile	III,IV	0.948	0.208	.024	12	view →
BRCA	OS	Tertile	IV	0.991	0.501	.005	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

HEIH–MESO (OS)

Open the MESO breakdown →