HECW2

Across TCGA patient cohorts, HECW2 protein abundance is significantly associated with the RNA expression of many other genes, with 7,896 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HECW2-associated genes across cancer lineages are GUCY1B1, GRID1, and RAPGEF5. Each is linked with HECW2 in more than 3 cancer types. Because this analysis shows association rather than direction, both HECW2-to-partner and partner-to-HECW2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HECW2 versus GUCY1B1 in GBM, with a Pearson correlation of 0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HECW2→partner) and Y-score (partner→HECW2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GUCY1B1 →	+0.759	+0.501	<.001	<.001	3	4
GBM	GRID1 →	+0.927	+0.473	<.001	<.001	3	3
GBM	RAPGEF5 →	+0.912	+0.440	<.001	<.001	3	3
LUAD	KIF13A →	+0.517	+0.289	<.001	.005	3	3
BRCA	FAM171B →	+1.035	+0.518	<.001	<.001	3	3
LUAD	NR3C2 →	+0.933	+0.277	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,896 associations by consensus.

HECW2 vs GUCY1B1 — GBM

Explore this scatter interactively →