HECW2-AS1

Across TCGA pan-cancer cohorts, HECW2-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated HECW2-AS1 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher HECW2-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HECW2-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

KIRP, ACC, and HNSC are the cancer types where HECW2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	II,III,IV	0.477	1.000	.001	67	view →
ACC	DFS	Tertile	All	0.388	0.794	<.001	67	view →
HNSC	DFS	Tertile	All	0.437	0.257	.001	58	view →
UVM	DFS	Tertile	All	0.366	0.674	<.001	54	view →
UCEC	DFS	Median	III,IV	0.702	0.447	.002	42	view →
STAD	OS	Median	II,III,IV	0.487	0.641	.009	40	view →
GBM	OS	Median	All	0.209	0.315	.002	39	view →
KIRC	DFS	Tertile	IV	0.193	0.425	.007	24	view →
PRAD	DFS	Tertile	All	0.898	0.720	.001	18	view →
LUAD	OS	Tertile	II,III,IV	0.862	0.666	.005	16	view →
READ	OS	Quartile	All	0.496	0.813	.003	9	view →
LAML	DFS	Quartile	All	0.581	0.280	.009	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

HECW2-AS1–KIRP (DFS)

Open the KIRP breakdown →