HECW2-AS1

Across TCGA pan-cancer cohorts, HECW2-AS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of HECW2-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where HECW2-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types HECW2-AS1 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, HNSC, and ESCA are the cancer types where HECW2-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HECW2-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−0.736	<.001	8	view →
HNSC	All	All	+0.258	.010	4	view →
ESCA	Male	All	+0.751	.013	2	view →
CHOL	All	All	+0.744	.020	2	view →
PRAD	All	All	+0.579	.027	2	view →
LUAD	All	All	+0.322	.013	2	view →
LIHC	Female	All	+0.121	.030	2	view →
THCA	All	IV	+0.782	.017	1	view →
KICH	All	All	−0.294	.037	1	view →
KIRC	Male	All	+0.136	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

HECW2-AS1–COAD

Open the COAD breakdown →