HECW1

Across TCGA patient cohorts, HECW1 mutation is significantly associated with the total protein of many other genes, with 87 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HECW1-associated genes across cancer lineages are TFRC, Cyclin-B1, and FASN. Each is linked with HECW1 in more than 4 cancer types. Because this analysis shows association rather than direction, both HECW1-to-partner and partner-to-HECW1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by HECW1-low versus HECW1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HECW1→partner) and Y-score (partner→HECW1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TFRC →	+0.592	+1.874	<.001	.047	3	5
LUAD	Cyclin-B1 →	+0.621	+3.584	<.001	.002	3	5
LUAD	FASN →	+0.337	+1.362	.025	.035	3	4
LUAD	PKC-delta_pS664 →	-0.137	-1.894	<.001	.014	3	4
COAD	PDCD4 →	-0.368	-2.070	.001	.001	3	4
COAD	Cyclin-E2 →	+0.304	+2.688	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 87 associations by consensus.

TFRC by HECW1 expression — LUAD

Explore this box plot interactively →