HECW1

Across TCGA cell cohorts, HECW1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,969 significant associations in total. BONE shows the largest number of these associations.

The most reproducible HECW1-associated GO terms across cancer lineages are Negative regulation of complement-dependent cytotoxicity, Elastin metabolic process, and Regulation of ATP-dependent activity. Each is linked with HECW1 in more than 10 cancer types. Because this analysis shows association rather than direction, both HECW1-to-partner and partner-to-HECW1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of complement-dependent cytotoxicity grouped by HECW1-low versus HECW1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HECW1→partner) and Y-score (partner→HECW1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of complement-dependent cytotoxicity →	+0.274	+1.665	<.001	<.001	3	11
BONE	Elastin metabolic process →	+0.312	+1.751	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Regulation of ATP-dependent activity →	+0.109	+1.079	.001	.004	3	10
BONE	Chaperone-mediated autophagy →	+0.150	+1.751	<.001	<.001	3	9
BONE	Negative regulation of activation of membrane attack complex →	+0.244	+1.665	<.001	<.001	3	9
BONE	Peptidyl-lysine oxidation →	+1.881	+1.797	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,969 associations by consensus.

Negative regulation of complement-dependent cytotoxicity by HECW1 expression — BONE

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