HECW1

Across TCGA cell cohorts, HECW1 mutation is significantly associated with the mutation status of many other genes, with 4,919 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HECW1-associated genes across cancer lineages are NID1, ITGAE, and SLIT2. Each is linked with HECW1 in more than 6 cancer types. Because this analysis shows association rather than direction, both HECW1-to-partner and partner-to-HECW1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NID1 grouped by HECW1-low versus HECW1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HECW1→partner) and Y-score (partner→HECW1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	NID1 →	+4.139	+3.541	.003	.003	1	7
BLOOD_Lymphoma	ITGAE →	+4.014	+4.969	.008	.008	1	7
OVARY	SLIT2 →	+4.217	+4.217	.001	.001	1	7
LARGE_INTESTINE	PNPLA6 →	+4.558	+2.013	<.001	<.001	1	7
BLOOD_Leukemia	SRCAP →	+1.848	+2.002	.004	.004	1	7
LARGE_INTESTINE	SYNE2 →	+1.121	+1.251	.006	.006	1	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,919 associations by consensus.

NID1 by HECW1 expression — CNS

Explore this box plot interactively →