HECTD4

Across TCGA patient cohorts, HECTD4 RNA expression is significantly associated with the protein abundance of many other proteins, with 17,186 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HECTD4-associated proteins across cancer lineages are SART3, HNRNPLL, and WDR5. Each is linked with HECTD4 in more than 6 cancer types. Because this analysis shows association rather than direction, both HECTD4-to-partner and partner-to-HECTD4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HECTD4 versus SART3 in LSCC, with a Pearson correlation of 0.56.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HECTD4→partner) and Y-score (partner→HECTD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SART3 →	+0.199	+0.520	<.001	<.001	3	7
HNSC	HNRNPLL →	+0.286	+0.616	<.001	<.001	3	5
GBM	WDR5 →	+0.283	+0.404	<.001	<.001	3	5
LSCC	WRNIP1 →	+0.479	+0.552	<.001	<.001	3	5
LSCC	MYEF2 →	+1.209	+0.464	<.001	<.001	3	5
LSCC	MBD3 →	+0.593	+0.510	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,186 associations by consensus.

HECTD4 vs SART3 — LSCC

Explore this scatter interactively →