HECTD4

Across TCGA pan-cancer cohorts, HECTD4 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated HECTD4 data layer compared with 12 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher HECTD4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HECTD4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SCLC show a favorable association.

MESO, HNSC, and SCLC are the cancer types where HECTD4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	II,III,IV	0.292	0.495	.001	91	view →
HNSC	DFS	Median	IV	0.413	0.211	<.001	77	view →
SCLC	DFS	Quartile	II,III,IV	0.762	0.289	<.001	70	view →
UCS	DFS	Median	IV	0.952	0.367	.001	36	view →
LIHC	DFS	Quartile	All	0.402	0.613	<.001	25	view →
LUSC	DFS	Median	III,IV	0.512	0.914	.006	25	view →
BRCA	DFS	Tertile	III,IV	0.919	0.791	.004	25	view →
KIRC	DFS	Median	All	0.740	0.510	.003	14	view →
OV	OS	Quartile	All	0.766	0.855	.023	12	view →
ACC	DFS	Median	All	0.528	0.785	.003	11	view →
THCA	OS	Tertile	II,III,IV	0.624	0.875	.006	11	view →
PAAD	DFS	Quartile	All	0.462	0.135	.008	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

HECTD4–MESO (OS)

Open the MESO breakdown →