HECTD4

Across TCGA patient cohorts, HECTD4 protein abundance is significantly associated with the protein abundance of many other proteins, with 22,287 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HECTD4-associated proteins across cancer lineages are CASP1, PTPN11, and HECTD4_T2500. Each is linked with HECTD4 in more than 6 cancer types. Because this analysis shows association rather than direction, both HECTD4-to-partner and partner-to-HECTD4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HECTD4 versus CASP1 in OV, with a Pearson correlation of -0.43.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HECTD4→partner) and Y-score (partner→HECTD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CASP1 →	-0.716	-0.328	<.001	<.001	3	7
BRCA	PTPN11 →	+0.314	+0.386	<.001	<.001	3	6
BRCA	HECTD4_T2500 →	+0.718	+0.321	<.001	<.001	3	6
GBM	GMFG →	-0.832	-0.312	<.001	<.001	3	5
OV	CASP4 →	-0.617	-0.391	.003	.003	3	5
GBM	EOGT →	-0.291	-0.221	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 22,287 associations by consensus.

HECTD4 vs CASP1 — OV

Explore this scatter interactively →