HECTD4

Across TCGA cell cohorts, HECTD4 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,526 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HECTD4-associated GO terms across cancer lineages are mRNA splice site recognition, Negative regulation of autophagy, and Negative regulation of myoblast fusion. Each is linked with HECTD4 in more than 17 cancer types. Because this analysis shows association rather than direction, both HECTD4-to-partner and partner-to-HECTD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mRNA splice site recognition grouped by HECTD4-low versus HECTD4-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HECTD4→partner) and Y-score (partner→HECTD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	mRNA splice site recognition →	+0.134	+1.781	<.001	<.001	3	18
LUNG_SCLC	Negative regulation of autophagy →	+0.088	+1.026	<.001	<.001	3	17
STOMACH	Negative regulation of myoblast fusion →	+0.143	+1.026	<.001	.002	3	17
STOMACH	Stress granule assembly →	+0.153	+0.866	.001	.008	3	17
STOMACH	Regulation of macroautophagy →	+0.104	+1.207	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Regulation of myoblast fusion →	+0.089	+1.009	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,526 associations by consensus.

mRNA splice site recognition by HECTD4 expression — BONE

Explore this box plot interactively →