HECTD4

Across TCGA cell cohorts, HECTD4 mutation is significantly associated with the RNA expression of many other genes, with 1,358 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HECTD4-associated genes across cancer lineages are COQ3, SGCB, and LBH. Each is linked with HECTD4 in more than 3 cancer types. Because this analysis shows association rather than direction, both HECTD4-to-partner and partner-to-HECTD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COQ3 grouped by HECTD4-low versus HECTD4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HECTD4→partner) and Y-score (partner→HECTD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	COQ3 →	+0.554	+1.780	.002	<.001	3	4
BLOOD_Leukemia	SGCB →	+1.160	+2.614	.002	.003	3	3
LUNG_NSCLC_LUAD	LBH →	-1.676	-2.548	.008	.006	3	3
LARGE_INTESTINE	TMED8 →	+0.482	+1.780	<.001	<.001	3	3
LARGE_INTESTINE	DTWD1 →	+0.691	+1.780	<.001	<.001	3	3
LARGE_INTESTINE	LANCL1 →	+0.682	+1.874	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,358 associations by consensus.

COQ3 by HECTD4 expression — LARGE_INTESTINE

Explore this box plot interactively →