HECTD4

Across TCGA cell cohorts, HECTD4 mutation is significantly associated with the mutation status of many other genes, with 5,206 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HECTD4-associated genes across cancer lineages are TRRAP, MYO5C, and CACNA1H. Each is linked with HECTD4 in more than 6 cancer types. Because this analysis shows association rather than direction, both HECTD4-to-partner and partner-to-HECTD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRRAP grouped by HECTD4-low versus HECTD4-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HECTD4→partner) and Y-score (partner→HECTD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TRRAP →	+3.930	+3.192	<.001	<.001	1	7
SOFT_TISSUE	MYO5C →	+4.193	+2.843	.007	.007	1	7
KIDNEY	CACNA1H →	+3.491	+3.201	.008	.008	1	6
BLOOD_Leukemia	SPEN →	+2.239	+2.409	<.001	<.001	1	6
STOMACH	CELSR1 →	+4.129	+2.700	.001	.001	1	6
STOMACH	ZFHX4 →	+2.392	+2.392	.003	.003	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,206 associations by consensus.

TRRAP by HECTD4 expression — SOFT_TISSUE

Explore this box plot interactively →