HECTD3

Across TCGA patient cohorts, HECTD3 protein abundance is significantly associated with the RNA expression of many other genes, with 19,025 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HECTD3-associated genes across cancer lineages are TFAP4, TTI1, and RBMX. Each is linked with HECTD3 in more than 5 cancer types. Because this analysis shows association rather than direction, both HECTD3-to-partner and partner-to-HECTD3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HECTD3 versus TFAP4 in COAD, with a Pearson correlation of -0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HECTD3→partner) and Y-score (partner→HECTD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TFAP4 →	-0.596	-0.202	<.001	.001	3	6
HNSC	TTI1 →	-0.627	-0.137	.004	.007	3	5
HNSC	RBMX →	-0.739	-0.134	.006	.002	3	5
COAD	GFI1 →	+0.748	+0.164	.001	<.001	3	5
LSCC	SLAMF6 →	+1.048	+0.248	<.001	<.001	3	5
HNSC	VKORC1L1 →	-0.625	-0.234	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,025 associations by consensus.

HECTD3 vs TFAP4 — COAD

Explore this scatter interactively →