HECTD3

Across TCGA pan-cancer cohorts, HECTD3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of HECTD3’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where HECTD3 RNA is repressed in tumor relative to normal tissue. In most cancer types HECTD3 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, STAD, and LIHC are the cancer types where HECTD3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HECTD3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−0.767	<.001	8	view →
STAD	All	II,III,IV	+0.719	.001	6	view →
LIHC	All	All	+0.482	<.001	6	view →
BLCA	All	All	+0.475	.001	6	view →
KIRC	All	All	+0.265	<.001	6	view →
KICH	All	All	−0.661	<.001	5	view →
THCA	Male	All	+0.356	<.001	5	view →
LUAD	All	II,III,IV	+0.296	.003	4	view →
BRCA	All	All	−0.222	<.001	4	view →
CHOL	Female	All	+1.630	<.001	3	view →
HNSC	Female	All	+0.495	.010	3	view →
READ	All	All	−0.522	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

HECTD3–COAD

Open the COAD breakdown →