HECTD3

Across TCGA patient cohorts, HECTD3 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HECTD3-associated genes across cancer lineages are mTOR_pS2448, 4E-BP1_pT37_T46, and Caspase-7-cleavedD198. Each is linked with HECTD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HECTD3-to-partner and partner-to-HECTD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by HECTD3-low versus HECTD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HECTD3→partner) and Y-score (partner→HECTD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.116	-1.765	.038	.014	3	2
UCEC	4E-BP1_pT37_T46 →	-0.516	-2.687	<.001	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.675	+2.242	.002	.005	3	2
UCEC	eEF2 →	+0.315	+2.169	.019	.003	3	1
UCEC	ERK2 →	+0.216	+2.906	.002	.001	2	2
UCEC	MEK1 →	+0.460	+2.662	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

mTOR_pS2448 by HECTD3 expression — UCEC

Explore this box plot interactively →