HECTD3

Across TCGA cell cohorts, HECTD3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,149 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HECTD3-associated GO terms across cancer lineages are Endosomal transport, Retrograde transport, endosome to Golgi, and Macroautophagy. Each is linked with HECTD3 in more than 15 cancer types. Because this analysis shows association rather than direction, both HECTD3-to-partner and partner-to-HECTD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endosomal transport grouped by HECTD3-low versus HECTD3-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HECTD3→partner) and Y-score (partner→HECTD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Endosomal transport →	+0.066	+0.766	<.001	<.001	3	16
SKIN	Retrograde transport, endosome to Golgi →	+0.071	+0.777	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Macroautophagy →	+0.077	+0.853	<.001	<.001	3	15
SKIN	Cytosolic transport →	+0.082	+0.843	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Process utilizing autophagic mechanism →	+0.049	+0.772	.002	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Autophagy →	+0.049	+0.772	.002	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,149 associations by consensus.

Endosomal transport by HECTD3 expression — SKIN

Explore this box plot interactively →