HECTD3

Across TCGA cell cohorts, HECTD3 mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HECTD3-associated genes across cancer lineages are OR14A2, DNAH8, and BHLHE23. Each is linked with HECTD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HECTD3-to-partner and partner-to-HECTD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR14A2 grouped by HECTD3-low versus HECTD3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HECTD3→partner) and Y-score (partner→HECTD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR14A2 →	+0.015	+3.475	.004	.006	3	2
LUNG_NSCLC_LUAD	DNAH8 →	+0.196	+3.977	<.001	.005	3	1
LUNG_NSCLC_LUAD	BHLHE23 →	+0.047	+3.947	<.001	.004	3	1
LUNG_NSCLC_LUAD	FTHL17 →	+2.174	+3.544	<.001	.009	3	1
LUNG_NSCLC_LUAD	RGR →	+0.020	+4.481	<.001	.001	3	1
LUNG_NSCLC_LUAD	ANKRD30BL →	+0.040	+3.734	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

OR14A2 by HECTD3 expression — BLOOD_Leukemia

Explore this box plot interactively →