HECA

Across TCGA patient cohorts, HECA mutation is significantly associated with the RNA expression of many other genes, with 4,350 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HECA-associated genes across cancer lineages are SIGLEC27P, FRG2MP, and MIR3661. Each is linked with HECA in more than 1 cancer types. Because this analysis shows association rather than direction, both HECA-to-partner and partner-to-HECA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIGLEC27P grouped by HECA-low versus HECA-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HECA→partner) and Y-score (partner→HECA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SIGLEC27P →	+0.046	+4.070	.007	.009	3	2
SKCM	FRG2MP →	+0.033	+4.147	<.001	.008	3	2
UCEC	MIR3661 →	+0.548	+1.557	<.001	<.001	3	2
UCEC	TRGJP1 →	+0.360	+1.696	<.001	.003	3	2
SKCM	RPL35P9 →	+0.249	+3.821	<.001	.003	3	2
SKCM	RNU6-1190P →	+0.432	+3.906	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,350 associations by consensus.

SIGLEC27P by HECA expression — COAD

Explore this box plot interactively →