HEBP1

Across TCGA pan-cancer cohorts, HEBP1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of HEBP1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where HEBP1 RNA is repressed in tumor relative to normal tissue. In most cancer types HEBP1 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

THCA, LUAD, and HNSC are the cancer types where HEBP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HEBP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	IV	−1.182	<.001	11	view →
LUAD	Female	III,IV	−0.843	<.001	8	view →
HNSC	Male	All	+0.509	<.001	8	view →
UCEC	All	All	−1.128	<.001	6	view →
KIRP	All	II,III,IV	+0.604	.002	6	view →
KIRC	Male	II,III,IV	−0.455	<.001	6	view →
BRCA	All	All	+0.236	.013	6	view →
LUSC	All	All	−0.299	.001	5	view →
LIHC	Female	All	−0.399	.009	4	view →
STAD	All	IV	+1.150	.028	1	view →
COAD	Female	IV	−0.390	.011	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

HEBP1–THCA

Open the THCA breakdown →