HEATR6

Across TCGA cell cohorts, HEATR6 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HEATR6-associated genes across cancer lineages are MYBPC3, MYF5, and IFNA16. Each is linked with HEATR6 in more than 1 cancer types. Because this analysis shows association rather than direction, both HEATR6-to-partner and partner-to-HEATR6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYBPC3 grouped by HEATR6-low versus HEATR6-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEATR6→partner) and Y-score (partner→HEATR6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MYBPC3 →	+0.024	+4.550	<.001	<.001	3	2
BLOOD_Lymphoma	MYF5 →	+0.008	+4.247	<.001	.004	3	1
BLOOD_Lymphoma	IFNA16 →	+0.010	+4.247	<.001	.004	3	1
BLOOD_Lymphoma	SLC7A13 →	+0.003	+4.247	<.001	.004	3	1
BLOOD_Lymphoma	OR4P4 →	+0.003	+4.247	<.001	.004	3	1
BLOOD_Lymphoma	OR4N5 →	+0.016	+4.247	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

MYBPC3 by HEATR6 expression — OVARY

Explore this box plot interactively →