HEATR6

Across TCGA pan-cancer cohorts, HEATR6 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated HEATR6 data layer compared with 7 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher HEATR6 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HEATR6 expression acts as an unfavorable survival marker, although some lineages such as PAAD and ESCA show a favorable association.

STAD, LIHC, and KIRC are the cancer types where HEATR6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	DFS	Median	IV	0.147	0.723	<.001	72	view →
LIHC	DFS	Tertile	All	0.437	0.645	<.001	62	view →
KIRC	DFS	Quartile	IV	0.215	0.646	<.001	39	view →
KIRP	OS	Tertile	II,III,IV	0.142	0.810	.006	38	view →
MESO	DFS	Median	III,IV	0.296	0.512	.016	32	view →
KICH	DFS	Median	II,III,IV	0.575	0.920	.006	30	view →
ACC	DFS	Median	All	0.415	0.732	.001	29	view →
PAAD	OS	Median	II,III,IV	0.709	0.407	<.001	25	view →
ESCA	OS	Quartile	II,III,IV	0.771	0.468	.002	23	view →
UCEC	DFS	Quartile	All	0.774	0.875	.007	18	view →
HNSC	DFS	Median	IV	0.424	0.309	.011	15	view →
CESC	DFS	Quartile	All	0.767	0.888	.008	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

HEATR6–STAD (DFS)

Open the STAD breakdown →