HEATR5A

Across TCGA pan-cancer cohorts, HEATR5A Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated HEATR5A data layer compared with 23 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher HEATR5A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HEATR5A expression acts as an unfavorable survival marker, although some lineages such as UCEC and SCLC show a favorable association.

LUSC, SKCM, and PRAD are the cancer types where HEATR5A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	II,III,IV	0.001	0.743	<.001	36	view →
SKCM	DFS	Median	IV	0.036	0.433	<.001	7	view →
PRAD	DFS	Median	All	0.617	0.886	.045	6	view →
HNSC	OS	Median	II,III,IV	0.174	0.601	.012	6	view →
UCEC	DFS	Median	All	0.952	0.827	.023	4	view →
SARC	OS	Median	All	0.201	0.766	.007	3	view →
SCLC	DFS	Median	All	1.000	0.463	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

HEATR5A–LUSC (OS)

Open the LUSC breakdown →