HEATR5A

Across TCGA pan-cancer cohorts, HEATR5A RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of HEATR5A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HEATR5A RNA is repressed in tumor relative to normal tissue. In most cancer types HEATR5A is over-expressed in tumor, although a few such as KIRC and COAD show the opposite, repressed pattern.

KIRC, COAD, and THCA are the cancer types where HEATR5A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HEATR5A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	III,IV	−0.672	<.001	11	view →
COAD	Female	All	−1.008	<.001	10	view →
THCA	All	II,III,IV	−0.512	<.001	8	view →
LIHC	Female	II,III,IV	+0.743	<.001	6	view →
STAD	All	II,III,IV	+0.424	.020	3	view →
LUSC	All	All	−0.322	<.001	3	view →
CHOL	All	All	+1.017	.002	2	view →
ESCA	All	II,III,IV	+0.330	.018	2	view →
PRAD	All	All	+0.291	.014	2	view →
READ	All	All	−0.576	.015	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

HEATR5A–KIRC

Open the KIRC breakdown →