HEATR5A

Across TCGA patient cohorts, HEATR5A mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HEATR5A-associated genes across cancer lineages are GAPDH, c-Met_pY1235, and C-Raf. Each is linked with HEATR5A in more than 2 cancer types. Because this analysis shows association rather than direction, both HEATR5A-to-partner and partner-to-HEATR5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by HEATR5A-low versus HEATR5A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEATR5A→partner) and Y-score (partner→HEATR5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GAPDH →	+0.775	+3.330	.001	.005	3	3
UCEC	c-Met_pY1235 →	+0.054	+1.512	.015	.017	3	3
UCEC	C-Raf →	+0.134	+1.736	.001	.006	3	3
COAD	14-3-3_epsilon →	+0.202	+2.212	<.001	.033	3	3
COAD	eIF4E →	+0.248	+2.195	.003	.034	3	2
UCEC	PCNA →	+0.233	+1.999	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

GAPDH by HEATR5A expression — COAD

Explore this box plot interactively →