HEATR1

Across TCGA patient cohorts, HEATR1 mutation is significantly associated with the RNA expression of many other genes, with 5,645 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HEATR1-associated genes across cancer lineages are PRC1, C4orf46, and LINC00987. Each is linked with HEATR1 in more than 3 cancer types. Because this analysis shows association rather than direction, both HEATR1-to-partner and partner-to-HEATR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRC1 grouped by HEATR1-low versus HEATR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEATR1→partner) and Y-score (partner→HEATR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRC1 →	+0.639	+2.710	<.001	<.001	3	4
UCEC	C4orf46 →	+0.470	+1.616	<.001	.002	3	4
UCEC	LINC00987 →	-0.354	-1.349	<.001	<.001	3	4
UCEC	MIR4768 →	-0.634	-1.381	.004	<.001	3	4
UCEC	MRPL39 →	+0.373	+1.802	<.001	<.001	3	4
UCEC	EXO1 →	+0.460	+1.593	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,645 associations by consensus.

PRC1 by HEATR1 expression — UCEC

Explore this box plot interactively →