HDX

Across TCGA patient cohorts, HDX RNA expression is significantly associated with the protein abundance of many other proteins, with 14,241 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HDX-associated proteins across cancer lineages are CALD1, TLN1, and LXN. Each is linked with HDX in more than 5 cancer types. Because this analysis shows association rather than direction, both HDX-to-partner and partner-to-HDX results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HDX versus CALD1 in UCEC, with a Pearson correlation of 0.24.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HDX→partner) and Y-score (partner→HDX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CALD1 →	+0.756	+0.696	.001	.001	3	6
UCEC	TLN1 →	+0.521	+0.834	<.001	<.001	3	6
OV	LXN →	+0.502	+0.426	.006	<.001	3	5
HNSC	FAM83H_S925 →	-0.519	-0.555	<.001	<.001	3	5
COAD	HDGFL3 →	+0.450	+0.278	<.001	.003	3	5
LSCC	PHLDB1 →	+0.465	+0.594	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,241 associations by consensus.

HDX vs CALD1 — UCEC

Explore this scatter interactively →