HDX

Across TCGA patient cohorts, HDX mutation is significantly associated with the RNA expression of many other genes, with 5,026 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HDX-associated genes across cancer lineages are SEC24D, ALKBH5, and FAM41AY2. Each is linked with HDX in more than 3 cancer types. Because this analysis shows association rather than direction, both HDX-to-partner and partner-to-HDX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEC24D grouped by HDX-low versus HDX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDX→partner) and Y-score (partner→HDX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SEC24D →	+0.685	+1.721	<.001	<.001	3	4
UCEC	ALKBH5 →	+0.498	+2.078	<.001	<.001	3	3
BRCA	FAM41AY2 →	+0.014	+4.878	<.001	.002	3	3
UCEC	NUS1 →	+0.456	+1.925	<.001	<.001	3	3
UCEC	ADAMTS13 →	-0.492	-1.533	<.001	<.001	3	3
UCEC	RARS1 →	+0.397	+1.721	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,026 associations by consensus.

SEC24D by HDX expression — UCEC

Explore this box plot interactively →