HDX

Across TCGA patient cohorts, HDX mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HDX-associated genes across cancer lineages are ATM, MEK1, and PCNA. Each is linked with HDX in more than 1 cancer types. Because this analysis shows association rather than direction, both HDX-to-partner and partner-to-HDX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by HDX-low versus HDX-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDX→partner) and Y-score (partner→HDX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.552	-2.991	.006	.036	3	2
UCEC	MEK1 →	+0.508	+2.765	<.001	<.001	3	2
UCEC	PCNA →	+0.145	+1.807	.019	.024	3	2
UCEC	Shc_pY317 →	-0.122	-1.152	.005	.048	3	2
UCEC	TIGAR →	+0.106	+1.026	.015	.028	3	2
UCEC	CD49b →	-0.205	-1.565	.012	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

ATM by HDX expression — COAD

Explore this box plot interactively →