HDX

Across TCGA cell cohorts, HDX RNA expression is significantly associated with the go_rna of many other GO terms, with 3,192 significant associations in total. BONE shows the largest number of these associations.

The most reproducible HDX-associated GO terms across cancer lineages are Nuclear membrane organization, Viral process, and Cytoplasmic translation. Each is linked with HDX in more than 9 cancer types. Because this analysis shows association rather than direction, both HDX-to-partner and partner-to-HDX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nuclear membrane organization grouped by HDX-low versus HDX-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HDX→partner) and Y-score (partner→HDX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Nuclear membrane organization →	+0.063	+0.767	.006	.005	2	10
LARGE_INTESTINE	Viral process →	+0.050	+0.625	<.001	.003	3	8
SKIN	Cytoplasmic translation →	+0.070	+1.275	<.001	<.001	3	8
BLOOD_Lymphoma	Host-mediated perturbation of viral process →	+0.056	+0.657	<.001	.005	3	8
BLOOD_Lymphoma	Cellular response to type I interferon →	+0.106	+0.890	<.001	<.001	3	8
SKIN	Microtubule polymerization or depolymerization →	+0.056	+0.818	.007	.003	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,192 associations by consensus.

Nuclear membrane organization by HDX expression — BONE

Explore this box plot interactively →