HDX

Across TCGA cell cohorts, HDX mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HDX-associated genes across cancer lineages are FGF23, TOPAZ1, and TRIM77. Each is linked with HDX in more than 1 cancer types. Because this analysis shows association rather than direction, both HDX-to-partner and partner-to-HDX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FGF23 grouped by HDX-low versus HDX-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDX→partner) and Y-score (partner→HDX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	FGF23 →	+0.013	+4.510	.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	TOPAZ1 →	+0.125	+4.357	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	TRIM77 →	+0.022	+4.357	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	FAM236A →	+0.090	+4.357	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	CSNKA2IP →	+0.011	+4.510	<.001	.003	3	1
BREAST	TRIM51 →	+0.176	+4.199	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

FGF23 by HDX expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →